Journal: bioRxiv
Article Title: Foveated Light-Field Compound Imager
doi: 10.64898/2026.03.23.713670
Figure Lengend Snippet: (A-C) Elemental (A), reconstructed FOLIC (B), and wide-field ground-truth (C) images of 15-µm fluorescent microspheres distributed in three layers. The dashed box in (A) outlines the sensor area. The arrows point to exemplary consistent features. (D-F) Reconstructed focal images by FOLIC at Δ Z 1 = 708 µm, Δ Z 2 = 837 µm, and Δ Z 3 = 963 µm, where peripheral, blend, and foveated zones were outlined. (G-I) Corresponding wide-field images at each layer, respectively. The arrows point to exemplary consistent features. Microsphere structures as narrow as ∼14 µm were consistently resolved in (F) and (I). (J) Elemental image of the central lenslet, which was employed as a mask to suppress noise and reconstruction artifacts. The green arrow indicates a pre-scaling feature displacement. (K) Corresponding wide-field images projected with 1250 axial stacks (step size = 2 µm). (L, M) Focal images of live HeLa cells embedded within a 2-mm-thick hydrogel, reconstructed by FOLIC at Δ Z 1 = 192 µm, Δ Z 2 = 966 µm. Peripheral, blend, and foveated zones were outlined. (N, O) Corresponding wide-field images at each layer, respectively. The arrows point to exemplary consistent features. (P, Q) Wide-field volume (P) and the corresponding reconstructed volume captured by FOLIC (Q), with clearly indicated foveated (red cones), blend (blue cones), and peripheral zones (single-layer view). Scale bars: 200 µm.
Article Snippet: A blue LED (M470L3, Thorlabs) was roughly collimated to provide wide-field illumination of the sample.
Techniques: